Wow...that makes absolutely no sense whatsoever Mousing over a BO within a designer doesn't do anything, so this is really strange. In fact, since a BO isn't a UI component and inherits from a Component within the component model, there are no UI events! So even if we wanted to do something in the mouse over within the designer or run-time...we couldn't!
You are welcome to post the solution and I will see if the same results happen on this side...but I have a feeling that there is something going in within your VS environment in regards to any Component or MarshalByRefComponent class.