The first thing that you need to understand is that StrataFrame uses itself. What I mean by this is that StrataFrame Connection, as you wanted to call it, is called the StrataFrame Data Store:This is the name that we call our connection. Any connection to a database or the connection wizard will be referred to, and is consistent within our posts and documentation, as a database connection.
The ApplicationKey is used as the unique identifiter that the database connection is stored under. In your AppMain.vb or program.cs file, there is a shared property that gets set and is named the Application which is used when the SetConnections() method is called. The framework looks in the externally stored connection table to see if there is an active database connection based on the ApplicationKey:
MicroFour.StrataFrame.Data.ConnectionManager.ApplicationKey = "MyApplicationKey"
To learn more read the documentation: Application -> WinForms -> Connection Strings