Yep, SQL Server 2012 is fully supported. For the DDT to work though, you will need to have the 2012 SMO objects installed. Which means you have to have SQL Server Management Studio 2012 installed on the machine from which you're deploying through the DDT. Or, include the 2012 SMO DLLs with the StrataFrame assemblies if you deploy a DDT package through the DDT.
Other than that, we just use the Native SQL Client, so yes, SQL Server 2012 is supported.