We want a ClickOnce deployment to users that would access data via web service.  This means that users don’t need to install via MSI or CD but install from the web (usng ClickOnce) the first time & then updates happen automatically.  Plus the data is shared via web service.  Is this possible out of the box in StrataGrame Framework?

This really has nothing to do with StrataFrame and is more related to how you decide to distribute your application.  We have a number of users who use ClickOnce deployment.  We found the ClickOnce somewhat limiting in larger environments and chose to write our own server for our medical software which hands out the installation to the clients...using MSI so we could create a more robust installation.  However, if ClickOnce meets your needs then StrataFrame will definitely work within that environment.