Standart Binding Source component has Datasource property. This is used to give a type for the control like a grid in design time. Then, At runtime an instance (Datatable) is binded to a control.

We are using Business Binding Source to bind an object to Devexpress Grid.

In my case, I have an instance object (Companies). But I have to drop that type of object on the form for informing the Devexpress grid. At Design time, I can easily manage the columns etc.

Is there any way to accomplish this without dropping Business Object on the form?

I am sorry, but I don't totally understand what you are trying to do.  I did understand that you don't want to drop a BO on the form, which is fine.  You can programmatically set a data source to a grid, or any other object for that matter, if you are wanting to create the BO in code and then set it at run-time.  It would just be a matter of setting the DataSource of the grid to a BBS that wraps the BO.  You can create this dynamically in code and then attach it so that you do not have to drop it on a form.