If you are using the SF sample database, try changing the name of the onnectionManager.ApplicationKey in your AppMain.vb class so it will create a new connection record.
This is just a guess
I have a simple one BO, one form project on a Vista 64bit system. When I do an F5, the form runs and the Database Connection Wizard appears. I setup the connection and the form loads and throws an error when I attempt to fill the BO.
The error is:-
DataLayerException An error occurred while creating a new DataLayer for the business object.DataLayerException The DataSourceKey [] is not defined.
Each time I do an F5 and run the project, the Database Connection Wizard always displays. From what I have read, it doesn't look like the wizard is saving the connection details as I believe it is supposed to only run the wizard once.
Have I missed something silly?
Thanks,
Aaron