The pertinent instructions from that help topic are pasted below:

IsWebEnvironment

The MicroFour.StrataFrame.Security.SecurityBasics class contains the shared (static) property IsWebEnvironment.  This property is used to indicate to the security module that the security is being run from within a web application and that the session objects should be used to store the CurrentUser and other session specific data. The IsWebEnvironment property should be set at the top of the Application_Start() method within the Global.asax file.

Imports MicroFour.StrataFrame.Security
...
Protected Sub Application_Start(ByVal sender As Object, ByVal e As EventArgs)
    '-- Set the property
    SecurityBasics.IsWebEnvironment = True
End Sub

using MicroFour.StrataFrame.Security;
...
protected void Application_Start(object sender, EventArgs e)
{
    //-- Set the property
    SecurityBasics.IsWebEnvironment = true;
}