Can you build SF in debug mode and break in the StrataFrameApplication.LoadLocalizationFromAssembly() method?  It would help to know what assembly is causing the error.

Saw that ealier and tried it again but doesn't help.

loadFromRemoteSources enabled="true"

Stack Trace:

   at System.Reflection.Emit.InternalAssemblyBuilder.GetManifestResourceNames()
   at MicroFour.StrataFrame.Application.StrataFrameApplication.LoadLocalizationFromAssembly(Assembly LoadedAssembly)
   at MicroFour.StrataFrame.Application.StrataFrameApplication.RunApplication()
   at IwSystemsCore.clsIwSystemsCore.Main(clsProcessing oStartProc, String fullAssemblyName) in c:\VssProjs\IwSystems\Development\IwApplications\IwSystemsMain\IwSystemsCore\SharedCore\IwSystemsCore.cs:line 188
   at IwSystemsStartup.IwSystemsStartupMain.Main() in c:\VssProjs\IwSystems\Development\IwApplications\IwSystemsMain\IwSystemsStartup\SharedStartup\IwSystemsStartupMain.cs:line 27
   at System.AppDomain._nExecuteAssembly(RuntimeAssembly assembly, String[] args)
   at System.AppDomain.nExecuteAssembly(RuntimeAssembly assembly, String[] args)
   at System.Runtime.Hosting.ManifestRunner.Run(Boolean checkAptModel)
   at System.Runtime.Hosting.ManifestRunner.ExecuteAsAssembly()
   at System.Runtime.Hosting.ApplicationActivator.CreateInstance(ActivationContext activationContext, String[] activationCustomData)
   at System.Runtime.Hosting.ApplicationActivator.CreateInstance(ActivationContext activationContext)
   at System.Activator.CreateInstance(ActivationContext activationContext)
   at Microsoft.VisualStudio.HostingProcess.HostProc.RunUsersAssemblyDebugInZone()
   at System.Threading.ThreadHelper.ThreadStart_Context(Object state)
   at System.Threading.ExecutionContext.RunInternal(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean preserveSyncCtx)
   at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean preserveSyncCtx)
   at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state)
   at System.Threading.ThreadHelper.ThreadStart()

What is the call stack of the exception that is thrown?  Does it contain Assembly.GetTypes() or AssemblyBuilder.GetTypes()?  Googling the error it seems as though the  .NET 4.0 runtime has tightened down the ability to use Assembly.Load dynamically to load assemblies that are not explicitly referenced, for instance, plug-ins.  There is an app.config setting that can allow them to run, though:

Yes.

Have you recompiled the SF source code in 4.0?

Trying to move from .Net 3.5 to 4.0 and I'm getting "The invoked member is not supported in a dynamic assembly." on this line:

StrataFrameApplication.RunApplication();

Any ideas???