If you want the business object to be able to copy data back into the database, you can create stored procedures to handle the inserting/updating/deleting of records from the business object.  Most likely, you'll want to use the GetDataTable() method of the business object rather than the FillDataTable and programmtically set the return value of the method to the DataSource of the DataGridView.  This way, you can circumvent the BusinessBindingSource and business object and just work with the data within the DataTable.

I have a DataGridView that is loaded with data from a readonly SQL view (actually via a SF BO). However, I do need to allow edits. I'd like to just react to the edit event, do my own thing (update data myself), cancel the editing that the datagridview attempts (which will fail), then update the gridview so it shows the new data. I'm sure this is easy, but I can't seem to get a handle on it. Ideas?