A style sheet just makes these types of things easier so you can go back and make a single change rather than having to dig back into your code. To see this in action, open up the Web Sample Application that comes with StrataFrame. Go to the SearchCustomers.aspx page and there is a ListView on that page that uses the HeaderCssClass tag, CssClass tag, and populates one of the columns through the RowPopulating event. I think that this will get you going in the right direction.