I am getting the following error. I believe the SQL references were added with SF? I'm not sure I remember having the same issue with  one touch deployment. I deleted the reference and eveything is ok just thought I would bring it up

Error 1 Invalid access to memory location. (Exception from HRESULT: 0x800703E6) S:\_Projects in Development\Paul's Projects\PortalReporting\WebSite\web.config 53 

web config line

<add assembly="Microsoft.SqlServer.Replication, Version=9.0.242.0, Culture=neutral, PublicKeyToken=89845DCD8080CC91"/></assemblies></compilation>

Yes...you are fine to remove this is you are not using replication.  The reason it adds this is because of the DBEngine and it's connections to SMO. 

Thanks Trent