Scott
We have one machine running Vista and VS2005 SP1. It runs, but there are some issues. The developer running with this configuration in our office is frustrated as the machine has a tendency to "throw-up." It just isn't 100% stable as of yet. We also threw Office 2007 in the mix as well which we have had some additional issues.
We have made some changes to the framework, specificaly in the DDT and data deployment areas, to support Vista. There are differences in the default encoding which can cause some issues. We can get you a build that has full Vista support if this is critical to your current needs. But I recommend waiting until we release the 1.5.2 update in January.
Thanks